Hydrogen Sulfide (H2S ) - Poison Gas to Signaling Molecule in Regulation of Human Biology
نویسندگان
چکیده
منابع مشابه
Gas signaling molecule hydrogen sulfide attenuates doxorubicin-induced dilated cardiomyopathy
Increasing evidence has revealed that hydrogen sulfide (H2S) has beneficial effects in the treatment of various cardiovascular diseases. However, whether H2S can attenuate the development of dilated cardiomyopathy (DCM) remains unclear. In this study, we generated a rat model of DCM induced by doxorubicin and investigated the protective effects of H2S against DCM. Cardiac structure and function...
متن کاملHydrogen sulfide (H2S) - the third gas of interest for pharmacologists.
Nitric oxide (NO) and carbon monoxide (CO) synthesized from L-arginine by NO synthase and from heme by heme oxygenase, respectively, are the well-known neurotransmitters and are also involved in the regulation of vascular tone. Recent studies suggest that hydrogen sulfide (H(2)S) is the third gaseous mediator in mammals. H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase...
متن کاملHydrogen sulfide, another simple gas with complex biology.
BACTERIAL INFECTIONS HAVE been one of the major scourges of humankind throughout history. Sepsis is recognized as a global health problem with an increasing incidence (5). The rate of hospitalization for sepsis more than doubled between 2000 and 2008 in the US (16). No monotherapy has been successful in improving mortality, including the recent failure of recombinant activated protein C to show...
متن کاملVascular biology of hydrogen sulfide.
Hydrogen sulfide (H2S) is a ubiquitous signaling molecule with important functions in many mammalian organs and systems. Observations in the 1990s ascribed physiological actions to H2S in the nervous system, proposing that this gasotransmitter acts as a neuromodulator. Soon after that, the vasodilating properties of H2S were demonstrated. In the past decade, H2S was shown to exert a multitude o...
متن کاملImplications of Hydrogen Sulfide in Glucose Regulation: How H2S Can Alter Glucose Homeostasis through Metabolic Hormones
Diabetes and its comorbidities continue to be a major health problem worldwide. Understanding the precise mechanisms that control glucose homeostasis and their dysregulation during diabetes are a major research focus. Hydrogen sulfide (H2S) has emerged as an important regulator of glucose homeostasis. This is achieved through its production and action in several metabolic and hormone producing ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of pharmacology & clinical research
سال: 2018
ISSN: 2473-5574
DOI: 10.19080/jpcr.2018.05.555661